AndrewsMommy
09-04-2006, 07:33 PM
to be on Reglan?
My son is 2 years old and has been on Reglan since 17 months of age. I was just wondering what effects he may get from being on this med long term? How long is safe? He gets 1.5 ml three times daily. He also takes Prevacid 15mg once a day, and Mylanta 2tsp three times a day.
graham
09-04-2006, 09:05 PM
Long-term use of this medication (>4 weeks) may be accompanied by increased side effects such as depression, although some patients have used it successfully for months.
Although disturbances such as galactorrhea, amenorrhea, gynecomastia and impotence have been reported with prolactin-elevating drugs such as this one, the more serious adverse reactions associated with the use of metoclopramide are parkinsonism and/or other extrapyramidal reactions. These consist often of a feeling of restlessness, facial spasms, involuntary movements and in some cases, muscular twitching, and oculogyric crisis. Dystonic reactions resembling tetanus have been reported. Extrapyramidal side effects appear to occur more frequently at dosages higher than the usual recommended dosage. Tardive dyskinesia, which in some cases appears to be irreversible, has been reported after discontinuation of long-term metoclopramide therapy. Therefore, prolonged treatment with metoclopramide should be avoided.
As with all medications, there is a risk/benefit consideration involved and in patients under 20 yrs of age, particularly those predisposed to depression or seizures. There is no magic cut-off time for therapy duration of metoclopramide but if you are concerned with or have a child experiencing any of the above movement disorders or depressive symptoms then talk about this with your doctor. Rapid discontinuation of this drug after months of continuous therapy is not recommended and shoud be undertaken in a gradual stepwise fashion with your doctor.
The usual dose for GERD is 0.1 to 0.2 mg/kg orally , IM or IV injection four times daily (max 0.8 mg/kg/day). The dose shoud be changed if the clearane from the kidneys is compromised.
Hope this answers your question, Graham Ph.C.