mom2evan
06-16-2006, 11:10 AM
I have noticed a lot of threads about the debate and/or facts about the suspension forms of PPIs vs the Packets. My son is currently on Prilosec flavored with grape. I understand that the flavoring can break down the PH, thus decreasing the potency of the drug. My pharmacy (Target) insists that it's good refrigerated up to 30 days even with the flavoring.
Now while reading MARCI-Kids I noticed that they strongly recommend the following:
(A Note About Pharmacy Compounds of PPIs
If you are currently giving your child a compounded suspension of a PPI such as Prilosec or Prevacid made by a pharmacy, you should know that there is a good potential for the medication to become inactive (and therefore ineffective) in a much shorter time period than your pharmacist may be aware. The loss of activity is related to the effect of the flavorings added by the pharmacies. The flavorings cause the PPI to become unstable and break down so it can no longer inhibit acid secretion. Laboratory testing has shown that the majority of such compounded, flavored preparations become inactive within a week.
In addition, many pharmacies do not add enough buffer in their suspensions to protect the drug from degradation by stomach acid. This is particularly a problem if the child is receiving a very low-volume dose—less than 3 mL, for example—because the amount of buffer likely won't be enough to protect the PPI from degradation by stomach acid.
For these reasons, we recommend the use of FDA-approved Zegerid® powder for oral suspension over the use of pharmacy-compounded suspensions, which are not FDA-approved.) Source: MARCI-Kids.
Can any of you share an experience where the packets worked better than the liquid form? I'm wondering if I should be concered about switching or if the liquid is just fine? My son in on 4ml which is considered a higher doseage.
Thanks!
Thanks
Now while reading MARCI-Kids I noticed that they strongly recommend the following:
(A Note About Pharmacy Compounds of PPIs
If you are currently giving your child a compounded suspension of a PPI such as Prilosec or Prevacid made by a pharmacy, you should know that there is a good potential for the medication to become inactive (and therefore ineffective) in a much shorter time period than your pharmacist may be aware. The loss of activity is related to the effect of the flavorings added by the pharmacies. The flavorings cause the PPI to become unstable and break down so it can no longer inhibit acid secretion. Laboratory testing has shown that the majority of such compounded, flavored preparations become inactive within a week.
In addition, many pharmacies do not add enough buffer in their suspensions to protect the drug from degradation by stomach acid. This is particularly a problem if the child is receiving a very low-volume dose—less than 3 mL, for example—because the amount of buffer likely won't be enough to protect the PPI from degradation by stomach acid.
For these reasons, we recommend the use of FDA-approved Zegerid® powder for oral suspension over the use of pharmacy-compounded suspensions, which are not FDA-approved.) Source: MARCI-Kids.
Can any of you share an experience where the packets worked better than the liquid form? I'm wondering if I should be concered about switching or if the liquid is just fine? My son in on 4ml which is considered a higher doseage.
Thanks!
Thanks